Isoxazole-5-carbonyl chloride → N-[4'-(2,4-Dioxothiazolidin-5-ylmethyl)biphenyl-3-ylmethyl]-N-methylisoxazole-5-carboxamide

HRID 584964노트

반응식

HRID 584964 반응식
FC(F)(F)C(O)=O.[CH3:8][NH:9][CH2:10][C:11]1[CH:12]=[C:13]([C:17]2[CH:22]=[CH:21][C:20]([CH2:23][CH:24]3[S:28][C:27](=[O:29])[NH:26][C:25]3=[O:30])=[CH:19][CH:18]=2)[CH:14]=[CH:15][CH:16]=1.[O:31]1[C:35]([C:36](Cl)=[O:37])=[CH:34][CH:33]=[N:32]1>>[O:29]=[C:27]1[NH:26][C:25](=[O:30])[CH:24]([CH2:23][C:20]2[CH:19]=[CH:18][C:17]([C:13]3[CH:14]=[CH:15][CH:16]=[C:11]([CH2:10][N:9]([CH3:8])[C:36]([C:35]4[O:31][N:32]=[CH:33][CH:34]=4)=[O:37])[CH:12]=3)=[CH:22][CH:21]=2)[S:28]1

참가 물질

3

반응물 2

HCID 2736707Isoxazole-5-carbonyl chlorideHCID 223414025-(3'-Methylaminomethylbiphenyl-4-ylmethyl)thiazolidine-2,4-dione trifluoroacetate

생성물 1

HCID 10112911N-[4'-(2,4-Dioxothiazolidin-5-ylmethyl)biphenyl-3-ylmethyl]-N-methylisoxazole-5-carboxamide

실험 절차

In a manner similar to that of Example 37(e), by reacting 500 mg (1.1 mmol) of 5-(3′-methylaminomethylbiphenyl-4-ylmethyl)thiazolidine-2,4-dione trifluoroacetate with 170 mg (1.3 mmol) of 5-isoxazolecarboxylic acid chloride, and after purification, 120 mg (26%) of N-[4′-(2,4-dioxothiazolidin-5-ylmethyl)biphenyl-3-ylmethyl]-N-methylisoxazole-5-carboxamide are obtained in the form of a white solid with a melting point of 160° C.

후처리

  1. customafter purification, 120 mg (26%) of N-[4′-(2,4-dioxothiazolidin-5-ylmethyl)biphenyl-3-ylmethyl]-N-methylisoxazole-5-carboxamide
  2. customare obtained in the form of a white solid with a melting point of 160° C.

출처 및 근거

ORD 기록
ord-a0edcbd8399a4d1a8c4a4bdf02db21b1
출처 데이터셋
uspto-grants-2005_08
특허 번호
US06927228B2

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