反应详情

In a manner similar to that of Example 37(e), by reacting 500 mg (1.1 mmol) of 5-(3′-methylaminomethylbiphenyl-4-ylmethyl)thiazolidine-2,4-dione trifluoroacetate with 170 mg (1.3 mmol) of 5-isoxazolecarboxylic acid chloride, and after purification, 120 mg (26%) of N-[4′-(2,4-dioxothiazolidin-5-ylmethyl)biphenyl-3-ylmethyl]-N-methylisoxazole-5-carboxamide are obtained in the form of a white solid with a melting point of 160° C.

1. customafter purification, 120 mg (26%) of N-[4′-(2,4-dioxothiazolidin-5-ylmethyl)biphenyl-3-ylmethyl]-N-methylisoxazole-5-carboxamide
2. customare obtained in the form of a white solid with a melting point of 160° C.