3,5-Dichlorobenzoyl chloride → 3,5-Dichloro-N-[4'-(2,4-dioxothiazolidin-5-ylmethyl)biphenyl-3-ylmethyl]-N-methylbenzamide

Participants

Reaction Steps

In a manner similar to that of Example 37(e), by reacting 1 g (2.2 mmol) of 5-(3′-methylaminomethyl-biphenyl-4-ylmethyl)thiazolidine-2,4-dione trifluoro-acetate with 350 μl (2.5 mmol) of 3,5-dichlorobenzoyl chloride, and after purification, 400 mg (50%) of 3,5-dichloro-N-[4′-(2,4-dioxothiazolidin-5-ylmethyl)-biphenyl-3-ylmethyl]-N-methylbenzamide are obtained in the form of a white solid with a melting point of 106° C.

Provenance & Evidence