2-Thiophenecarbonyl chloride → N-[4'-(2,4-dioxothiazolidin-5-ylmethyl)biphenyl-3-ylmethyl]-N-methylthiophene-2-carboxamide

Participants

Reaction Steps

In a manner similar to that of Example 37(e), by reacting 1 g (2.2 mmol) of 5-(3′-methylaminomethyl-biphenyl-4-ylmethyl)thiazolidine-2,4-dione trifluoro-acetate with 200 μl (2.5 mmol) of 2-thiophenecarboxylic acid chloride, and after purification, 500 mg (50%) of N-[4′-(2,4-dioxothiazolidin-5-ylmethyl)biphenyl-3-ylmethyl]-N-methylthiophene-2-carboxamide are obtained in the form of a white solid with a melting point of 160° C.

Provenance & Evidence