Heptanoyl chloride → HCID 69792650, compound

HRID 584983Notes

Reaction equation

HRID 584983 reaction equation
[CH3:1][NH:2][CH2:3][C:4]1[CH:5]=[C:6]([C:10]2[CH:15]=[CH:14][C:13]([CH:16]=[C:17]([CH2:22][C:23]([O:25][CH2:26][CH3:27])=[O:24])[C:18]([O:20][CH3:21])=[O:19])=[CH:12][CH:11]=2)[CH:7]=[CH:8][CH:9]=1.[C:28](Cl)(=[O:35])[CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34]>>[C:28]([N:2]([CH2:3][C:4]1[CH:5]=[C:6]([C:10]2[CH:15]=[CH:14][C:13]([CH:16]=[C:17]([CH2:22][C:23]([O:25][CH2:26][CH3:27])=[O:24])[C:18]([O:20][CH3:21])=[O:19])=[CH:12][CH:11]=2)[CH:7]=[CH:8][CH:9]=1)[CH3:1])(=[O:35])[CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34]

Participants

3

Reactant 2

HCID 17313Heptanoyl chlorideHCID 69792685HCID 69792685, compound

Product 1

HCID 69792650HCID 69792650, compound

Procedure

In a manner similar to that of Example 37(e), by reacting 1.5 g (4.2 mmol) of methyl ethyl 2-(3′-methylaminomethylbiphenyl-4-ylmethylene)succinate with 740 μl (4.8 mmol) of heptanoyl chloride, and after purification, 1.8 g (89%) of the expected product are obtained.

Workup

  1. customafter purification, 1.8 g (89%) of the expected product
  2. customare obtained

Sources & evidence

ORD record
ord-03df2e6d21ef48e2a454d56090b706a4
Source dataset
uspto-grants-2005_08
Patent number
US06927228B2

Reaction notes

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