3-Bromophenol → 4-(3-hydroxyphenyl)benzaldehyde

HRID 584985Notes

Reaction equation

HRID 584985 reaction equation
Br[C:2]1[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.[CH:9]([C:11]1[CH:16]=[CH:15][C:14](B(O)O)=[CH:13][CH:12]=1)=[O:10]>>[OH:8][C:4]1[CH:3]=[C:2]([C:14]2[CH:15]=[CH:16][C:11]([CH:9]=[O:10])=[CH:12][CH:13]=2)[CH:7]=[CH:6][CH:5]=1

Participants

3

Reactant 2

HCID 115633-BromophenolHCID 5910734-Formylphenylboronic Acid

Product 1

HCID 27592964-(3-hydroxyphenyl)benzaldehydeYield 65.8%

Procedure

In a manner similar to that of Example 1(e), starting with 20 g (115 mmol) of 3-bromophenol and 26 g (173 mmol) of 4-formylbenzene boronic acid, 15 g (65%) of the expected product are obtained.

Sources & evidence

ORD record
ord-0c930150d89548e09780440a1fed1abb
Source dataset
uspto-grants-2005_08
Patent number
US06927228B2

Reaction notes

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