4-Formyl-2-methylphenylboronic acid → Tert-butyl (4'-formyl-2'-methylbiphenyl-3-ylmethyl)-n-methylcarbamate

Participants

Reaction Steps

In a manner similar to that of Example 1(e), by reacting 6.1 g (20.3 mmol) of tert-butyl (3-bromo benzyl)-N-methylcarbamate with 4.3 g (26.2 mmol) of 2-methyl-4-formylbenzene boronic acid, and after purification by chromatography on a column of silica eluted with a heptane/ethyl acetate mixture (8/2), 4 g (58%) of the expected product are obtained in the form of an orange oil.

Provenance & Evidence