Thiazolidinedione → Tert-butyl [4'-(2,4-dioxothiazolidin-5-ylidenemethyl)-2'-methylbiphenyl-3-ylmethyl]-n-methylcarbamate

Participants

Reaction Steps

In a manner similar to that of Example 1(f), by reacting 3.95 g (11.6 mmol) of tert-butyl (4′-formyl-2′-methylbiphenyl-3-ylmethyl)-N-methylcarbamate with 1.4 g (11.6 mmol) of 2,4-thiazolidine dione, and after purification by chromatography on a column of silica eluted with a heptane/ethyl acetate mixture (8/2), 3 g (59%) of the expected product are obtained in the form of a yellow solid with a melting point of 156° C.

Provenance & Evidence