tert-Butyl 3-bromobenzyl(methyl)carbamate → Tert-butyl (4'-formyl-3'-methylbiphenyl-3-ylmethyl)-n-methylcarbamate

Participants

Reaction Steps

In a manner similar to that of Example 1(e), by reacting 1.1 g (3.5 mmol) of tert-butyl (3-bromo-benzyl)-N-methylcarbamate obtained in Example 79(b) with 750 mg (4.6 mmol) of 3-methyl-4-formylbenzene-boronic acid, and after purification by chromatography on a column of silica eluted with a heptane/ethyl acetate mixture (7/3), 1 g (87%) of the expected product is obtained in the form of a yellow oil.

Provenance & Evidence