Phenyl isocyanate → HCID 90951067, compound

HRID 585012Notes

Reaction equation

[CH2:1]([NH:3][C:4]1[CH:5]=[C:6]([C:10]2[CH:15]=[CH:14][C:13]([CH:16]=[C:17]3[S:21][C:20](=[O:22])[NH:19][C:18]3=[O:23])=[CH:12][CH:11]=2)[CH:7]=[CH:8][CH:9]=1)[CH3:2].[C:24]1([N:30]=[C:31]=[O:32])[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>>[O:22]=[C:20]1[NH:19][C:18](=[O:23])[C:17](=[CH:16][C:13]2[CH:12]=[CH:11][C:10]([C:6]3[CH:7]=[CH:8][CH:9]=[C:4]([N:3]([CH2:1][CH3:2])[C:31]([NH:30][C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)=[O:32])[CH:5]=3)=[CH:15][CH:14]=2)[S:21]1

Participants

Reactant 2

HCID 7672Phenyl isocyanate

HCID 73884095HCID 73884095, compound

Product 1

HCID 90951067HCID 90951067, compoundYield 95.2%

Procedure

In a manner similar to that of Example 9(a), by reacting 500 mg (1.54 mmol) of 5-(3′-ethylamino-biphenyl-4-ylmethylene)thiazolidine-2,4-dione with 340 μl (3.1 mmol) of phenyl isocyanate, 650 mg (95%) of the expected product are obtained in the form of a yellow solid.

Sources & evidence

ORD record: ord-86f37295037948ea8eef17420e1641ac
Source dataset: uspto-grants-2005_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06927228B2

Reaction notes

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