Sec-Butylamine → HCID 178448526, compound

HRID 585035Notes

Reaction equation

HRID 585035 reaction equation
[SH:1][C:2]1O[CH:4]=[CH:5][N:6]=1.[CH:7]([NH2:11])([CH2:9][CH3:10])[CH3:8]>C(O)C>[CH:7]([N:11]1[CH:4]=[CH:5][N:6]=[C:2]1[SH:1])([CH2:9][CH3:10])[CH3:8]

Participants

4

Reactant 2

HCID 24874Sec-ButylamineHCID 178527879HCID 178527879, compound

Product 1

HCID 178448526HCID 178448526, compoundYield 54%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1 g (9.89 mmol) of 2-mercaptooxazole and 0.72 g (9.89 mmol) of sec-butylamine were dissolved in 20 ml of ethanol and refluxed for 2 hours. After cooling, the solvent was distilled off under reduced pressure and the residue was treated with column chromatography to obtain 0.83 g of 1-sec-butyl-2-mercaptoimidazole. mp.=108-121° C., yield 54%.

Workup

  1. temperaturerefluxed for 2 hours
  2. temperatureAfter cooling
  3. distillationthe solvent was distilled off under reduced pressure
  4. additionthe residue was treated with column chromatography

Sources & evidence

ORD record
ord-0b2968fc78974837b13c82daeb78e866
Source dataset
uspto-grants-2005_08
Patent number
US06930076B2

Reaction notes

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