反应详情

1 g (9.89 mmol) of 2-mercaptooxazole and 0.72 g (9.89 mmol) of sec-butylamine were dissolved in 20 ml of ethanol and refluxed for 2 hours. After cooling, the solvent was distilled off under reduced pressure and the residue was treated with column chromatography to obtain 0.83 g of 1-sec-butyl-2-mercaptoimidazole. mp.=108-121° C., yield 54%.

1. temperaturerefluxed for 2 hours
2. temperatureAfter cooling
3. distillationthe solvent was distilled off under reduced pressure
4. additionthe residue was treated with column chromatography