Hydrochloric Acid → HCID 10027302, compound

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Reaction Steps

Into a vial are placed methyl 2-({[2-[(4-cyanophenyl)amino]-5-(trifluoromethyl)phenyl]amino}sulfonyl)benzoate (289 mg, 0.608 mmol), 1M NaOH (10 mL), and MeOH (10 mL). The mixture is efficiently shaken at rt for 16 h. 1M HCl is added to adjust the pH to 1. The precipitated was filtered and purified by preparative thin layer chromatography. The yield is 65 mg of 2-({[2-[(4-cyanophenyl)amino]-5-(trifluoromethyl)phenyl]amino}sulfonyl)benzoic acid, 23%. 1H NMR (400 MHz, DMSO-d6): □ 10.92 (s, 1 H), 9.98 (s, 1 H), 7.58-7.56 (m, 3 H), 7.44-7.43 (m, 2 H), 7.38-7.30 (m, 3 H), 7.21-7.17 (m, 1 H), 7.02-7.00 (m, 2 H). HRMS for C21H14F3N3O4S 462.0754 (M+H)+.

Provenance & Evidence