Hydrochloric Acid → HCID 22339361, compound

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Reaction Steps

Into a vial is placed 2-({[2-[(4-{[(tert-butoxycarbonyl)amino]methyl}phenyl)(methyl)amino]-5-(trifluoromethyl)phenyl]amino}carbonyl)-4,5-dichlorobenzoic acid (34 mg, 0.056 mmol) and MeOH (5 mL) saturated with HCl. The mixture is stirred at rt for 2 h. The solution is concentrated and the product purified by preparative thin layer chromatography. The yield is 12 mg of 2-({[2-[[4-(aminomethyl)phenyl](methyl)amino]-5-(trifluoromethyl)phenyl]amino}carbonyl)-4,5-dichlorobenzoic acid, 42%. DMSO: 13.3 (s, 1 H), 8.48 (s, 1 H), 7.76 (s, 2 H), 7.51 (m, 1 H), 7.41 (m, 1 H), 7.16 (m, 2 H), 6.60-6.58 (m, 2 H), 3.81 (s, 2 H), 3.22 (s, 3 H). ESI+ for C23H18Cl2F3N3O3 497 (M+H)+.

Provenance & Evidence