反应详情

4.5 g (10.31 mmol) of ethyl 8,9-dimethoxy-3-methyl-2-(3-nitrophenyl)-5,6-dihydropyrrolo[2,1-a]isoquinoline-1-carboxylate (Example 2) were dissolved in 500 mL of warm methanol, 2.03 g of 10% strength palladium on charcoal were added, and the compound was hydrogenated at atmospheric pressure. The reaction mixture was filtered through a filter aid, the filtrate was evaporated under reduced pressure to a volume of approx. 150 mL, and the resulting precipitate was filtered off to give the title compound.

1. filtrationThe reaction mixture was filtered through a filter aid
2. customthe filtrate was evaporated under reduced pressure to a volume of approx. 150 mL
3. filtrationthe resulting precipitate was filtered off