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1-(3-chlorophenyl)-1H-pyrrole-2-carbaldehyde → 3-[N-(3-chlorophenyl)pyrrol-2-yl]-5-acetylaminoindolin-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(3-chlorophenyl)-1H-pyrrole-2-carbaldehyde | HCID 3710040 | — |
| 反応物 | N-(2-oxoindolin-5-yl)acetamide | HCID 11206280 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 3-[N-(3-chlorophenyl)pyrrol-2-yl]-5-acetylaminoindolin-2-one | HCID 10109452 | 17% |
反応手順
By carrying out the procedure as in Example 1, but starting with 1.05 g (5 mmol) of 5-acetylaminoindolin-2-one in 150 ml of ethanol and 0.95 g (10 mmol) of 3-[N-(3-chlorophenyl)pyrrole-2-carboxaldehyde, 0.32 g (17%) of 3-[N-(3-chlorophenyl)pyrrol-2-yl]-5-acetylaminoindolin-2-one is obtained in the form of an orange solid whose characteristic is the following: melting point=251° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06930124B2 |
| 出典データセット | uspto-grants-2005_08 |
| ORD ID | ord-46ec22cd25af44129e93cecded2b6137 |
| 出典メモ | uspto-grants-2005_08 |