Nitric Acid → HCID 22339380, compound

HRID 585130Notes

Reaction equation

HRID 585130 reaction equation
[N+:1]([O-:4])(O)=[O:2].[Cl:5][C:6]1[CH:7]=[C:8]([N:22]2[C:27](=[O:28])[NH:26][C:25](=[O:29])[CH:24]=[N:23]2)[CH:9]=[C:10]([Cl:21])[C:11]=1[O:12][C:13]1[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=1.O>C(O)(=O)C>[Cl:5][C:6]1[CH:7]=[C:8]([N:22]2[C:27](=[O:28])[NH:26][C:25](=[O:29])[CH:24]=[N:23]2)[CH:9]=[C:10]([Cl:21])[C:11]=1[O:12][C:13]1[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[C:15]([N+:1]([O-:4])=[O:2])[CH:14]=1

Participants

5

Reactant 3

HCID 944Nitric AcidHCID 962WaterHCID 22339608HCID 22339608, compound

Product 1

HCID 22339380HCID 22339380, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
0 °C

Procedure

To a cooled (0° C.), stirred solution of nitric acid (20 mL) in acetic acid (65 mL) was added 2-[3,5-dichloro-4-(4-methoxy-phenoxy)-phenyl]-2H-[1,2,4]triazine-3,5-dione (5.0 g) and the resulting mixture was allowed to stir at ambient temperature for 1.5 h. The resulting solution was poured into 400 mL of water, the resulting solids filtered and dried to afford the title compound of Step A as a yellow solid, 5.1 g. MS Calc.:425.2; Found: 422.9.

Workup

  1. filtrationthe resulting solids filtered
  2. customdried

Sources & evidence

ORD record
ord-4bc3dd359a9a4404a2351092c6270e77
Source dataset
uspto-grants-2005_08
Patent number
US06930107B2

Reaction notes

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