Boron tribromide → HCID 22339542, compound

Participants

Reaction Steps

To a solution of 1-{5-[2,6-dichloro-4-(3,5-dioxo-4-(2-trimethylsilanyl-ethoxy-methyl)4,5-dihydro-3H-[1,2,4]triazin-2-yl)-phenoxy]-2-methoxy-phenyl}-3-(4-trifluoromethoxy-phenyl)-urea (72 mg, 0.1 mmol) in CH2Cl2 was added dropwise BBr3 (1M in CH2Cl2, 4.0 mL, 0.4 mmol). The mixture was stirred at room temperature for 18 h and quenched with water (10 mL). After stirring at room temperature for 1 h, the quenched mixture was extracted with CH2Cl2 (3×10 mL). The combined CH2Cl2 extracts were dried and concentrated. The residue was purified by preparative TLC (10% MeOH in CH2Cl2) to afford the title compound (25.4 mg) of this EXAMPLE. MS Calc.:584.3 Found:581.8 (M−1).

Provenance & Evidence