Boron Trichloride → HCID 22339735, compound

Participants

Reaction Steps

To a stirred solution of 2-{3-chloro-4-[3-(benzenesulfonyl)-4-methoxy-phenoxy]-5-methyl-phenyl}-2H-[1,2,4]triazine-3,5-dione (0.66 g) in dichloromethane (12 mL) was added boron trichloride (8 mL, 1M in dichloromethane) and the resulting solution was stirred for 4 h. The reaction solution was poured onto ice, allowed to stir for 1 h, the phases separated and the aqueous layer washed with dichloromethane. The combined organic layers were dried (Na2SO4) and concentrated to afford the title compound of this EXAMPLE as a tan foam, 0.52 g. m.p. 78-81° C.

Provenance & Evidence