HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 585149Generated: October 30, 2026
Cyclohexanemethanol → 2-[4-(3-Bromo-4-methoxy-phenoxy)-3,5-dimethyl-phenyl]-3,5-dioxo-2,3,4,5-tetrahydro-[1,2,4]triazine-6-carboxylic acid cyclohexylmethyl ester
https://huagongshe.com/reaction/585149
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cyclohexanemethanol | HCID 7507 | — |
| Reactant | Diisopropylcarbodiimide | HCID 12734 | — |
| Reactant | 2-[4-(3-Bromo-4-methoxy-phenoxy)-3,5-dimethyl-phenyl]-3,5-dioxo-2,3,4,5-tetrahydro-[1,2,4]triazine-6-carboxylic acid | HCID 22339438 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-[4-(3-Bromo-4-methoxy-phenoxy)-3,5-dimethyl-phenyl]-3,5-dioxo-2,3,4,5-tetrahydro-[1,2,4]triazine-6-carboxylic acid cyclohexylmethyl ester | HCID 69707281 | — |
Reaction Steps
To a solution of cyclohexylmethanol (9 μmol) in DMF were added sequentially solutions of 2-[4-(3-bromo-4-methoxy-phenoxy)-3,5-dimethyl-phenyl]-3,5-dioxo-2,3,4,5-tetrahydro-[1,2,4]triazine-6-carboxylic acid (5 μmol), diisopropylcarbodiimide (10 mmol) and 4-dimethylaminopyridine (10 μmol). The resulting soution was shaken at 50° C. for 18 h. HPLC and LCMS shows the starting material to be consumed and the desired product present. MS Calc.: 557.1; Found: 556.1 (M−1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06930107B2 |
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| Source dataset | uspto-grants-2005_08 |
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| ORD ID | ord-b3cffc801c164c65999a44147a04a8fa |
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| Source note | uspto-grants-2005_08 |
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