Hydrochloric Acid → HCID 22340553, compound

Participants

Reaction Steps

30.7 g (100 mmol) of 2,3-diphenyl-thienylcarbonic acid dimethylamide was mixed with 100 ml ether and the resulting suspension was added in some portions at 0° C. to solution of 1-stiryllitium prepared from 62 ml 1.6M BuLi in hexane (100 mmol) and 27 g 1-bromostyrene (150 mmol) in 200 ml ether. The mixture warmed to room temperature (r.t.) and was stirred for 1 h. The resulting solution was poured into 500 ml of 5% aqueous HCl. The organic phase was collected, separated from insoluble impurities, washed with water, dried over MgSO4 and evaporated to give 20.9 g (57%) of crystalline solid. The product can be contaminated with 5-10% of starting amide (by NMR) and can be used without further purification.

Provenance & Evidence