HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene-4-sulfonic acid 2-(2-cyclohexyl-5-methyloxazol-4-yl)-ethyl ester → (S)-3-{4-[2-(2-Cyclohexyl-5-methyl-oxazol-4-yl)-ethoxy]-phenyl}-2-methyl-2-(4-trifluoromethyl-phenoxy)-propionic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene-4-sulfonic acid 2-(2-cyclohexyl-5-methyloxazol-4-yl)-ethyl ester | HCID 22340021 | — |
| Reactant | HCID 69318029 | HCID 69318029 | — |
| Product | (S)-3-{4-[2-(2-Cyclohexyl-5-methyl-oxazol-4-yl)-ethoxy]-phenyl}-2-methyl-2-(4-trifluoromethyl-phenoxy)-propionic Acid | HCID 60024300 | — |
Reaction Steps
The title compound was prepared from (S)-3-(4-hydroxyphenyl)-2-methyl-2-(4-trifluoromethyl-phenoxy)-propionic acid ethyl ester (95% ee; Chiralpak AD separation, 8×27 cm, 10% IPA/heptane, 275 nm) and toluene-4-sulfonic acid 2-(2-cyclohexyl-5-methyl-oxazol-4-yl)-ethyl ester by the procedure described in Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06930120B2 |
| Source dataset | uspto-grants-2005_08 |
| ORD ID | ord-495485bc40594071b065ec79f0a9577b |
| Source note | uspto-grants-2005_08 |