Thionyl Chloride → HCID 22340304, compound

Participants

Reaction Steps

To the N-[2-(hydroxymethyl)-6-quinolinyl]acetamide (1.00 g, 4.62 mmol) obtained in Reference Example 5 was added thionyl chloride (23 ml) under ice-cooling, and the mixture was stirred for 2 hours. The reaction solution was concentrated under reduced pressure, and the resulting residue was washed with ethyl acetate to obtain the titled compound (900 mg) as a powder.

Provenance & Evidence