反应详情

Dissolve 4-(cyclopropylcarbonyl)benzeneacetic acid in ethanol (150 mL) containing concentrated sulfuric acid (10 drops). Stir 24 hours. Add triethylamine (2 mL) and concentrate the solution. Dissolve the residue in water/ethyl acetate. Wash the organic phase with saturated sodium hydrogen carbonate solution, dry over anhydrous magnesium sulfate and concentrate. Purify by silica gel chromatography (400 mL silica gel, 20% ethyl acetate/heptane as eluent) to give the title compound (7.0 g, 88%).

1. concentrationAdd triethylamine (2 mL) and concentrate the solution
2. dissolutionDissolve the residue in water/ethyl acetate
3. washWash the organic phase with saturated sodium hydrogen carbonate solution
4. dry with materialdry over anhydrous magnesium sulfate
5. concentrationconcentrate
6. customPurify by silica gel chromatography (400 mL silica gel, 20% ethyl acetate/heptane as eluent)