HRID585367

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID16641028

1'-Benzyl-1,2-dihydrospiro[indole-3,4'-piperidine]

C19H22N2

结构：COc1ccc(C(=O)N2c3ccccc3[C@H](O)C[C@@H]2C)cc1OC

HCID69774154

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(C(=O)N2c3ccccc3C(N3CC4(CCN(Cc5ccccc5)CC4)c4ccccc43)CC2C)cc1OC

HCID22339235

未命名化合物

收率 52.4%

PROCEDURE

实验过程

Starting with cis-1-(3,4-dimethoxybenzoyl)-2-methyl-1,2,3,4-tetrahydro-4-quinolinol (400 mg, 1.22 mmol) prepared in Reference Example 1 and 1′-benzylspiro[indoline-3,4′-piperidine] (849 mg, 3.05 mmol), the same procedure as shown in Example 1 was repeated to give the titled compound (376 mg, yield: 44%) as a colorless oil. (cis:trans=1:1.5)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-41b24b28573b4c52889c841e1d77e01b
来源数据集: uspto-grants-2005_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06930104B2
来源说明: uspto-grants-2005_08

反应 SMILES

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:20]=[CH:21][C:22]=1[O:23][CH3:24])[C:6]([N:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C@H:11](O)[CH2:10][C@@H:9]1[CH3:19])=[O:7].[CH2:25]([N:32]1[CH2:37][CH2:36][C:35]2([C:45]3[C:40](=[CH:41][CH:42]=[CH:43][CH:44]=3)[NH:39][CH2:38]2)[CH2:34][CH2:33]1)[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>>[CH2:25]([N:32]1[CH2:37][CH2:36][C:35]2([C:45]3[C:40](=[CH:41][CH:42]=[CH:43][CH:44]=3)[N:39]([CH:11]3[C:12]4[C:17](=[CH:16][CH:15]=[CH:14][CH:13]=4)[N:8]([C:6](=[O:7])[C:5]4[CH:20]=[CH:21][C:22]([O:23][CH3:24])=[C:3]([O:2][CH3:1])[CH:4]=4)[CH:9]([CH3:19])[CH2:10]3)[CH2:38]2)[CH2:34][CH2:33]1)[C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1