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Indoline → 4-(2,3-Dihydro-1H-indol-1-yl)-1-(3,4-dimethoxybenzoyl)-2-methyl-1,2,3,4-tetrahydroquinoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Indoline | HCID 10328 | — |
| 反応物 | cis-1-(3,4-Dimethoxybenzoyl)-2-methyl-1,2,3,4-tetrahydro-4-quinolinol | HCID 69774154 | — |
| 生成物 | 4-(2,3-Dihydro-1H-indol-1-yl)-1-(3,4-dimethoxybenzoyl)-2-methyl-1,2,3,4-tetrahydroquinoline | HCID 22339337 | 51.1% |
反応手順
Starting with cis-1-(3,4-dimethoxybenzoyl)-2-methyl-1,2,3,4-tetrahydro-4-quinolinol (400 mg, 1.22 mmol) prepared in Reference Example 1 and indoline (436 mg, 3.66 mmol), the same procedure as shown in Example 1 was repeated to give the titled compound (267 mg, yield: 51%) as a white crystal. (cis:trans=1:1.8)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06930104B2 |
| 出典データセット | uspto-grants-2005_08 |
| ORD ID | ord-2a2ba6d015aa43bd9d450e37407a073a |
| 出典メモ | uspto-grants-2005_08 |