2,3-Dihydro-1,4-benzothiazine → HCID 10115515, compound

HRID 585373Notes

Reaction equation

HRID 585373 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:20]=[CH:21][C:22]=1[O:23][CH3:24])[C:6]([N:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C@H:11](O)[CH2:10][C@@H:9]1[CH3:19])=[O:7].[S:25]1[C:30]2[CH:31]=[CH:32][CH:33]=[CH:34][C:29]=2[NH:28][CH2:27][CH2:26]1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:20]=[CH:21][C:22]=1[O:23][CH3:24])[C:6]([N:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:11]([N:28]2[C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=3[S:25][CH2:26][CH2:27]2)[CH2:10][CH:9]1[CH3:19])=[O:7]

Participants

3

Reactant 2

HCID 1510642,3-Dihydro-1,4-benzothiazineHCID 69774154cis-1-(3,4-Dimethoxybenzoyl)-2-methyl-1,2,3,4-tetrahydro-4-quinolinol

Product 1

HCID 10115515HCID 10115515, compoundYield 25%

Procedure

Starting with cis-1-(3,4-dimethoxybenzoyl)-2-methyl-1,2,3,4-tetrahydro-4-quinolinol (1.00 g, 2.93 mmol) prepared in Reference Example 1 and 3,4-dihydro-2H-1,4-benzothiazine (1.22 g, 8.07 mmol), the same procedure as shown in Example 1 was repeated to give the titled compound (335 mg, yield: 25%) as a white crystal. (cis:trans=1.5:1)

Sources & evidence

ORD record
ord-cfee2c85cf084d3395f5b4e8d6bffdcb
Source dataset
uspto-grants-2005_08
Patent number
US06930104B2

Reaction notes

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