1,2,3,4-Tetrahydroisoquinoline → 1-(3,4-Dimethoxybenzoyl)-2-methyl-4-(1,2,3,4-tetrahydroisoquinolin-2-yl)-1,2,3,4-tetrahydroquinoline

Participants

Reaction Steps

Starting with cis-1-(3,4-dimethoxybenzoyl)-2-methyl-1,2,3,4-tetrahydro-4-quinolinol (400 mg, 1.22 mmol) prepared in Reference Example 1 and 1,2,3,4-tetrahydroisoquinoline (487 mg, 3.66 mmol), the same procedure as shown in Example 1 was repeated to give the titled compound (210 mg, yield: 39%) as a white crystal. (cis:trans=1:1)

Provenance & Evidence