HRID585383

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1cc(C(=O)N2c3ccccc3C(O)CC2C)cc(OC)c1OC

HCID22339230

未命名化合物

HCID22339349

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)CCCCOc1ccc2c(c1)CCCN2C1CC(C)N(C(=O)c2cc(OC)c(OC)c(OC)c2)c2ccccc21

HCID22339267

未命名化合物

收率 40%

PROCEDURE

实验过程

Starting with 2-methyl-1-(3,4,5-trimethoxybenzoyl)-1,2,3,4-tetrahydro-4-quinolinol (1.3 g, 3.6 mmol) prepared in Reference Example 22 and ethyl 5-[(1,2,3,4-tetrahydro-6-quinolinyl)oxy]pentanoate (2.30 g, 8.28 mmol), the same procedure as shown in Example 1 was repeated to give the titled compound (806 mg, yield: 40%) as a colorless oil. (cis:trans=1:1.3)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-bb0e467e4ba740f8a9332e07f5d9e10a
来源数据集: uspto-grants-2005_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06930104B2
来源说明: uspto-grants-2005_08

反应 SMILES

[CH3:1][CH:2]1[CH2:11][CH:10](O)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]1[C:13](=[O:26])[C:14]1[CH:19]=[C:18]([O:20][CH3:21])[C:17]([O:22][CH3:23])=[C:16]([O:24][CH3:25])[CH:15]=1.[NH:27]1[C:36]2[C:31](=[CH:32][C:33]([O:37][CH2:38][CH2:39][CH2:40][CH2:41][C:42]([O:44][CH2:45][CH3:46])=[O:43])=[CH:34][CH:35]=2)[CH2:30][CH2:29][CH2:28]1>>[CH3:1][CH:2]1[CH2:11][CH:10]([N:27]2[C:36]3[C:31](=[CH:32][C:33]([O:37][CH2:38][CH2:39][CH2:40][CH2:41][C:42]([O:44][CH2:45][CH3:46])=[O:43])=[CH:34][CH:35]=3)[CH2:30][CH2:29][CH2:28]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]1[C:13](=[O:26])[C:14]1[CH:15]=[C:16]([O:24][CH3:25])[C:17]([O:22][CH3:23])=[C:18]([O:20][CH3:21])[CH:19]=1