HRID585392

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11736340

4-[3-(trifluoromethyl)phenyl]piperidine

C12H14F3N

结构：COc1ccc(C(=O)N2c3ccccc3C(n3c4ccccc4c4ccccc43)CC2CCCCCO)cc1OC

HCID22339233

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(C(=O)N2c3ccccc3C(n3c4ccccc4c4ccccc43)CC2CCCCCN2CCC(c3cccc(C(F)(F)F)c3)CC2)cc1OC

HCID22339347

未命名化合物

收率 53.5%

PROCEDURE

实验过程

Starting with 5-[4-(9H-9-carbazolyl)-1-(3,4-dimethoxybenzoyl)-1,2,3,4-tetrahydro-2-quinolinyl]-1-pentanol (0.19 g, 0.32 mmol) prepared in Example 135 and 4-[3-(trifluoromethyl)phenyl]piperidine (0.23 g, 1 mmol), the same procedure as shown in Example 136 was repeated to give the titled compound (0.13 g, yield: 53%) as a white crystal (cis:trans=3:1).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-eb711abbb77f45098a00c173954b7cb2
来源数据集: uspto-grants-2005_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06930104B2
来源说明: uspto-grants-2005_08

反应 SMILES

[CH:1]1[C:13]2[N:12]([CH:14]3[C:23]4[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=4)[N:17]([C:24](=[O:35])[C:25]4[CH:30]=[CH:29][C:28]([O:31][CH3:32])=[C:27]([O:33][CH3:34])[CH:26]=4)[CH:16]([CH2:36][CH2:37][CH2:38][CH2:39][CH2:40]O)[CH2:15]3)[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH:4]=[CH:3][CH:2]=1.[F:42][C:43]([F:57])([F:56])[C:44]1[CH:45]=[C:46]([CH:50]2[CH2:55][CH2:54][NH:53][CH2:52][CH2:51]2)[CH:47]=[CH:48][CH:49]=1>>[CH3:34][O:33][C:27]1[CH:26]=[C:25]([CH:30]=[CH:29][C:28]=1[O:31][CH3:32])[C:24]([N:17]1[C:18]2[C:23](=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:14]([N:12]2[C:13]3[CH:1]=[CH:2][CH:3]=[CH:4][C:5]=3[C:6]3[C:11]2=[CH:10][CH:9]=[CH:8][CH:7]=3)[CH2:15][CH:16]1[CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][N:53]1[CH2:52][CH2:51][CH:50]([C:46]2[CH:47]=[CH:48][CH:49]=[C:44]([C:43]([F:42])([F:56])[F:57])[CH:45]=2)[CH2:55][CH2:54]1)=[O:35]