Ethyl bromoacetate → HCID 10229780, compound

Participants

Reaction Steps

Preparation of (1-benzyl-2-ethyl-1H-benzo[f]indol-4-yloxy)acetic acid benzyl ester. A mixture of 1-benzyl-2-ethyl-1,9-dihydrobenzo[f]indol-4-one (200 mg, 0.67 mmol), cesium carbonate (436 mg, 1.39 mmol), and ethyl bromoacetate (0.21 mL, 1.34 mmol) in N,N-dimethylformamide (5 mL) was stirred at room temperature for 20 h. The mixture was diluted with water and the resulting solution extracted three times with ethyl acetate. The combined ethyl acetate extracts were washed three times with water, filtered through a plug of silica gel, and concentrated in vacuo. Chromatography (hexane/methylene chloride) of the residue provided 120 mg (40%) of the title compound as a yellow film.

Provenance & Evidence