HCID 178515085, compound → HCID 178507381, compound

Participants

Reaction Steps

A solution of 4-nitro-2-[3-(silylmethyl)benzyl]-1-isoindolinone (5.2 g, 12.5 mmol) in tetrahydrofuran (60 ml) is, in the presence of palladium (10% on carbon, 375 mg), stirred under an atmosphere of hydrogen for 20 h and filtered, and the filtrate is concentrated under reduced pressure. The desired product is purified by flash chromatography (cyclohexane/ethyl acetate mixtures). Yield: 3.8 g, 79% of theory.

Provenance & Evidence