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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 585529Generated: October 27, 2026

3,4-Difluorobenzaldehyde → Methyl(S)-3-[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]-2-(3,4-difluorobenzylamino)propionate

https://huagongshe.com/reaction/585529

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3,4-DifluorobenzaldehydeHCID 588088—
ReactantEthyl(S)-3-[4-[2-[5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]ethoxy]phenyl]-2-(4-fluorobenzylamino)propionateHCID 12149026—
ProductMethyl(S)-3-[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]-2-(3,4-difluorobenzylamino)propionateHCID 69732100—

Reaction Steps

In the same manner as in Example 7, 213.3 mg of the title compound was obtained as colorless amorphous compound from 490.8 mg of Referential Compound 3 and 215 μL of 3,4-difluorobenzaldehyde.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06933309B2
Source datasetuspto-grants-2005_08
ORD IDord-8b82e197559c45b0863551335421fe3f
Source noteuspto-grants-2005_08