Methanesulfonic Acid → HCID 86592457, compound

Participants

Reaction Steps

Methanesulfonic acid (7.8 mL) was added to a solution of Compound 1 (50.2 g) in ethanol (150 mL), and the temperature of the solution was elevated to 40° C. The solution was stirred for 10 minutes, and the reactor was cooled in an ice bath. When the interior temperature reached 10° C. or lower, diisopropyl ether (300 mL) was added thereto, and the mixture was left to stand for night and day in a dark cold place. The product was collected through filtration with a glass filter and dried under reduced pressure, to thereby yield 52.1 g of the title compound as colorless crystals.

Provenance & Evidence