HCID 60024503, compound → HCID 60024506, compound

HRID 585568Notes

Reaction equation

HRID 585568 reaction equation
[CH3:1][O:2][C:3](=[O:15])[CH2:4][C@H:5]1[CH2:7][C@@H:6]1[C:8]([O:10]C(C)(C)C)=[O:9]>FC(F)(F)C(O)=O.C(Cl)Cl>[CH3:1][O:2][C:3](=[O:15])[CH2:4][C@H:5]1[CH2:7][C@@H:6]1[C:8]([OH:10])=[O:9]

Participants

3

Reactant 1

HCID 60024503HCID 60024503, compound

Product 1

HCID 60024506HCID 60024506, compound

Reagents, catalysts & solvents 1

HCID 21863450Trifluoroacetic acid methylene chlorideSolvent

Procedure

Tert-butyl (1S,2R)-2-(2-methoxy-2-oxoethyl)cyclopropanecarboxylate was dissolved in a mixture of trifluoroacetic acid:methylene chloride (7:3) and stirred at room temperature until the t-butyl ester was removed. The solvent was removed under reduced pressure to give product. 1H NMR (CDCl3) δ 3.70 (s, 3H), 2.35 (d, J=7.5 Hz, 2H), 1.85-1.70 (m, 1H), 1.52-1.49 (m, 1H), 1.39-1.30 (m, 1H), 0.93-0.87 (m, 1H).

Workup

  1. customwas removed
  2. customThe solvent was removed under reduced pressure
  3. customto give product

Sources & evidence

ORD record
ord-fd668ca683c343d3bba421880491d5a4
Source dataset
uspto-grants-2005_08
Patent number
US06933304B2

Reaction notes

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