HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 3-(5-{4-[4-(3-Fluorobenzyloxy)-3-chloroanilino]-6-quinazolinyl}-2-furyl)-2-propenoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl 3-(5-{4-[4-(3-fluorobenzyloxy)-3-chloroanilino]-6-quinazolinyl}-2-furyl)-2-propenoate | HCID 68874066 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-(5-{4-[4-(3-Fluorobenzyloxy)-3-chloroanilino]-6-quinazolinyl}-2-furyl)-2-propenoic acid | HCID 68874729 | — |
Reaction Steps
Prepared according to Procedure H utilizing ethyl 3-(5-{4-[4-(3-fluorobenzyloxy)-3-chloroanilino]-6-quinazolinyl}-2-furyl)-2-propenoate (0.50 g) and aqueous sodium hydroxide (2M, 2 mL) in THF (6 mL) to afford the title compound (0.46 9). Electrospray MS m/z 516 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06933299B1 |
| Source dataset | uspto-grants-2005_08 |
| ORD ID | ord-24cbed83a65e40c0973d8f5dd023b014 |
| Source note | uspto-grants-2005_08 |