HCID 69619670, compound → HCID 22337460, compound

HRID 585726Notes

Reaction equation

HRID 585726 reaction equation
C[O:2][C:3]([C:5]1[CH:14]=[CH:13][C:12]2[CH:11]([NH:15][C:16]([O:18][CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[O:17])[CH2:10][CH2:9][CH2:8][C:7]=2[CH:6]=1)=[O:4]>[OH-].[Na+]>[CH2:19]([O:18][C:16]([NH:15][CH:11]1[CH2:10][CH2:9][CH2:8][C:7]2[CH:6]=[C:5]([C:3]([OH:4])=[O:2])[CH:14]=[CH:13][C:12]1=2)=[O:17])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

3

Reactant 1

HCID 69619670HCID 69619670, compound

Product 1

HCID 22337460HCID 22337460, compoundYield 83.2%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

By a similar reaction operation as in Starting Material Synthetic Example 8 using 5-(benzyloxycarbonylamino)-5,6,7,8-tetrahydronaphthalene-2-carboxylic acid methyl ester (3.50 g) and 1N aqueous sodium hydroxide solution (20 ml), the objective 5-(benzyloxycarbonylamino)-5,6,7,8-tetrahydronaphthalene-2-carboxylic acid (2.79 g) was obtained as colorless crystals.

Sources & evidence

ORD record
ord-7749352248f24defad608376ebc4f1fe
Source dataset
uspto-grants-2005_08
Patent number
US06933305B2

Reaction notes

Loading…