Sodium Hydroxide → HCID 22337461, compound

HRID 585734Notes

Reaction equation

HRID 585734 reaction equation
C[O:2][C:3]([C:5]1[CH:14]=[C:13]2[C:8]([CH:9]([NH:15][C:16]([O:18][CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[O:17])[CH2:10][CH2:11][O:12]2)=[CH:7][CH:6]=1)=[O:4].[OH-].[Na+]>>[CH2:19]([O:18][C:16]([NH:15][CH:9]1[C:8]2[C:13](=[CH:14][C:5]([C:3]([OH:4])=[O:2])=[CH:6][CH:7]=2)[O:12][CH2:11][CH2:10]1)=[O:17])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 69619662HCID 69619662, compound

Product 1

HCID 22337461HCID 22337461, compoundYield 93.3%

Procedure

By a similar reaction operation as in Starting Material Synthetic Example 8 using 4-(benzyloxycarbonylamino)chromane-7-carboxylic acid methyl ester (1.9 g) and 1N sodium hydroxide (14 ml), the objective 4-(benzyloxycarbonylamino)chromane-7-carboxylic acid (1.7 g) was obtained as colorless crystals.

Sources & evidence

ORD record
ord-63b57b4111414d1097fde0804b44b108
Source dataset
uspto-grants-2005_08
Patent number
US06933305B2

Reaction notes

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