HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Aminopyridine → 4-(tert-butoxycarbonylamino)-6-methyl-N-(4-pyridyl)thiochromane-7-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Aminopyridine | HCID 1727 | — |
| Reactant | 2-Chloro-1-methylpyridinium iodide | HCID 167069 | — |
| Reactant | 4-(Tert-butoxycarbonylamino)-6-methylthiochromane-7-carboxylic acid | HCID 22337379 | — |
| Product | 4-(tert-butoxycarbonylamino)-6-methyl-N-(4-pyridyl)thiochromane-7-carboxamide | HCID 22337377 | 67.5% |
Reaction Steps
By a similar reaction operation as in Starting Material Synthetic Example 53 using 4-(tert-butoxycarbonylamino)-6-methylthiochromane-7-carboxylic acid (1.00 g), 4-aminopyridine (321 mg) and 2-chloro-1-methylpyridinium iodide (949 mg), the objective 4-(tert-butoxycarbonylamino)-6-methyl-N-(4-pyridyl)thiochromane-7-carboxamide (834 mg) was obtained as colorless crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06933305B2 |
| Source dataset | uspto-grants-2005_08 |
| ORD ID | ord-377a95a185fe48a086ff3b6818dac67d |
| Source note | uspto-grants-2005_08 |