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2-Chloro-1-methylpyridinium iodide → (S)-4-(tert-butoxycarbonylamino)-6-methyl-N-(1-triphenylmethylpyrazolo[3,4-b]pyridin-4-yl)thiochromane-7-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Chloro-1-methylpyridinium iodide | HCID 167069 | — |
| 反応物 | 4-Amino-1-triphenylmethylpyrazolo[3,4-b]pyridine | HCID 22337470 | — |
| 反応物 | HCID 59089485 | HCID 59089485 | — |
| 生成物 | (S)-4-(tert-butoxycarbonylamino)-6-methyl-N-(1-triphenylmethylpyrazolo[3,4-b]pyridin-4-yl)thiochromane-7-carboxamide | HCID 69619661 | 72.8% |
反応手順
By a similar reaction operation as in Starting Material Synthetic Example 53 using (S)-4-(tert-butoxycarbonylamino)-6-methylthiochromane-7-carboxylic acid (500 mg), 4-amino-1-triphenylmethylpyrazolo[3,4-b]pyridine (641 mg) and 2-chloro-1-methylpyridinium iodide (474 mg), the objective (S)-4-(tert-butoxycarbonylamino)-6-methyl-N-(1-triphenylmethylpyrazolo[3,4-b]pyridin-4-yl)thiochromane-7-carboxamide (767 mg) was obtained as a pale yellow amorphous solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06933305B2 |
| 出典データセット | uspto-grants-2005_08 |
| ORD ID | ord-f4d41998ccc34aa989bc6c64dff12cf9 |
| 出典メモ | uspto-grants-2005_08 |