Potassium Carbonate → 4-(Tert-butoxycarbonylamino)-6-chlorothiochromane-7-carboxylic acid
Reaktionsgleichung
C[O:2][C:3]([C:5]1[CH:14]=[C:13]2[C:8]([CH:9]([NH:15][C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH2:10][CH2:11][S:12]2)=[CH:7][C:6]=1[Cl:23])=[O:4].C(=O)([O-])[O-].[K+].[K+]>>[C:19]([O:18][C:16]([NH:15][CH:9]1[C:8]2[C:13](=[CH:14][C:5]([C:3]([OH:4])=[O:2])=[C:6]([Cl:23])[CH:7]=2)[S:12][CH2:11][CH2:10]1)=[O:17])([CH3:22])([CH3:20])[CH3:21]Komponenten
3
Versuchsvorschrift
By a similar reaction operation as in Starting Material Synthetic Example 6 using 4-(tert-butoxycarbonylamino)-6-chlorothiochromane-7-carboxylic acid methyl ester (700 mg) and potassium carbonate (541 mg), the objective 4-(tert-butoxycarbonylamino)-6-chlorothiochromane-7-carboxylic acid (424 mg) was obtained as colorless crystals.
Quellen und Nachweise
- ORD-Eintrag
- ord-3d6589ed582e4f4d83943e283ac64443
- Quelldatensatz
- uspto-grants-2005_08
- Patentnummer
- US06933305B2
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