4-Aminopyridine → 4-(tert-butoxycarbonylamino)-6-chloro-N-(4-pyridyl)thiochromane-7-carboxamide

HRID 585757Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 585757
[C:1]([O:5][C:6]([NH:8][CH:9]1[C:18]2[C:13](=[CH:14][C:15]([C:20](O)=[O:21])=[C:16]([Cl:19])[CH:17]=2)[S:12][CH2:11][CH2:10]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH2:23][C:24]1[CH:29]=[CH:28][N:27]=[CH:26][CH:25]=1.[I-].ClC1C=CC=C[N+]=1C>>[C:1]([O:5][C:6]([NH:8][CH:9]1[C:18]2[C:13](=[CH:14][C:15]([C:20]([NH:23][C:24]3[CH:29]=[CH:28][N:27]=[CH:26][CH:25]=3)=[O:21])=[C:16]([Cl:19])[CH:17]=2)[S:12][CH2:11][CH2:10]1)=[O:7])([CH3:3])([CH3:2])[CH3:4]

Komponenten

4

Edukt 3

HCID 17274-AminopyridineHCID 1670692-Chloro-1-methylpyridinium iodideHCID 223374074-(Tert-butoxycarbonylamino)-6-chlorothiochromane-7-carboxylic acid

Produkt 1

HCID 223373584-(tert-butoxycarbonylamino)-6-chloro-N-(4-pyridyl)thiochromane-7-carboxamideAusbeute 104,1 %

Versuchsvorschrift

By a similar reaction operation as in Starting Material Synthetic Example 53 using 4-(tert-butoxycarbonylamino)-6-chlorothiochromane-7-carboxylic acid (200 mg), 4-aminopyridine (54.7 mg) and 2-chloro-1-methylpyridinium iodide (178 mg), the objective 4-(tert-butoxycarbonylamino)-6-chloro-N-(4-pyridyl)thiochromane-7-carboxamide (254 mg) was obtained as a colorless amorphous solid.

Quellen und Nachweise

ORD-Eintrag
ord-8016fd75b4be4148974fe3a22b170d09
Quelldatensatz
uspto-grants-2005_08
Patentnummer
US06933305B2

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