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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 585758Generated: October 26, 2026

Potassium Carbonate → (S)-4-(tert-butoxycarbonylamino)-6-chlorothiochromane-7-carboxylic acid

https://huagongshe.com/reaction/585758

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPotassium CarbonateHCID 11430—
Reactant(S)-4-(tert-butoxycarbonylamino)-6-chlorothiochromane-7-carboxylic acid methyl esterHCID 59089434—
Product(S)-4-(tert-butoxycarbonylamino)-6-chlorothiochromane-7-carboxylic acidHCID 5908943387.1%

Reaction Steps

By a similar reaction operation as in Starting Material Synthetic Example 6 using (S)-4-(tert-butoxycarbonylamino)-6-chlorothiochromane-7-carboxylic acid methyl ester (1.10 g) and potassium carbonate (847 mg), the objective (S)-4-(tert-butoxycarbonylamino)-6-chlorothiochromane-7-carboxylic acid (921 mg) was obtained as colorless crystals.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06933305B2
Source datasetuspto-grants-2005_08
ORD IDord-457c7b7d47e14f559d6fca5707853da1
Source noteuspto-grants-2005_08