Cyclohexanemethylamine → 1-(Cyclohexylmethyl)-2-oxopyrrolidine-3-carboxylic acid

HRID 58577Notes

Reaction equation

HRID 58577 reaction equation
CC1(C)[O:9][C:8](=[O:10])[C:5]2([CH2:7][CH2:6]2)[C:4](=[O:11])O1.[CH:13]1([CH2:19][NH2:20])[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1>C(O)C>[CH:13]1([CH2:19][N:20]2[CH2:6][CH2:7][CH:5]([C:8]([OH:9])=[O:10])[C:4]2=[O:11])[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1

Participants

4

Reactant 2

HCID 76688CyclohexanemethylamineHCID 797206,6-Dimethyl-5,7-dioxaspiro(2.5)octane-4,8-dione

Product 1

HCID 668319371-(Cyclohexylmethyl)-2-oxopyrrolidine-3-carboxylic acidYield 86.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

This compound was prepared according to general method 1 starting from 6,6-dimethyl-5,7-dioxaspiro[2.5]octane-4,8-dione (0.250 g, 1.47 mmol) and cyclohexylmethanamine (0.574 mL; 4.41 mmol) in ethanol (3 mL). 1-(cyclohexylmethyl)-2-oxopyrrolidine-3-carboxylic acid 0.286 g (86%) was obtained as a yellow solid.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-4bcd7e7ae6c34c8bba730cf21262651f
Source dataset
uspto-grants-2016_09
Patent number
US09434722B2

Reaction notes

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