反应详情

温度

30 °C

Pantoprazole free base (25 grams) was dissolved in a solution of acetonitrile (175 ml) and aqueous sodium hydroxide solution (2.7 grams in 5 ml of water) and stirred at a temperature of 25-35° C. till the clear solution results. The reaction solution was filtered through hyflow and washed the bed with acetonitrile (25 ml). Isopropyl ether (225 ml) was added slowly to the filtrate over a period of about ½ hour and the filtrate was stirred for about 1-2 hours to crystallize the solid mass. The separated solid mass was cooled to a temperature of 5-10° C. and further stirred for 3-4 hours. The solid was filtered, washed with Isopropyl ether (25 ml) and suck dried under vacuum. The wet solid was further dried at a temperature of 40-50° C. to afford crystalline Form-I of Pantoprazole sodium sesquihydrate.

1. customresults
2. filtrationThe reaction solution was filtered through hyflow
3. washwashed the bed with acetonitrile (25 ml)
4. additionIsopropyl ether (225 ml) was added slowly to the filtrate over a period of about ½ hour
5. stirringthe filtrate was stirred for about 1-2 hours
6. customto crystallize the solid mass
7. temperatureThe separated solid mass was cooled to a temperature of 5-10° C.
8. stirringfurther stirred for 3-4 hours
9. filtrationThe solid was filtered
10. washwashed with Isopropyl ether (25 ml)
11. customsuck dried under vacuum
12. customThe wet solid was further dried at a temperature of 40-50° C.