Ethyl trifluoroacetate → N-(2,3-dihydro-1H-inden-2-yl)-2,2,2-trifluoroacetamide

HRID 585799Notes

Reaction equation

[NH2:1][CH:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3]1.[F:11][C:12]([F:19])([F:18])[C:13](OCC)=[O:14]>>[CH2:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[CH2:10][CH:2]1[NH:1][C:13](=[O:14])[C:12]([F:19])([F:18])[F:11]

Participants

Reactant 2

HCID 9794Ethyl trifluoroacetate

HCID 763102-Aminoindane

Product 1

HCID 10307996N-(2,3-dihydro-1H-inden-2-yl)-2,2,2-trifluoroacetamide

Procedure

Preferably in Step (i), 2-aminoindan is reacted with ethyl trifluoroacetate to form N-(2,3-dihydro-1H-inden-2-yl)-2,2,2-trifluoroacetamide.

Sources & evidence

ORD record: ord-1a1572d03ddd478690cae56093a849c8
Source dataset: uspto-grants-2005_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06933410B2

Reaction notes

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