N-(5-acetyl-6-ethyl-2,3-dihydro-1H-inden-2-yl)-2,2,2-trifluoroacetamide → N-(5,6-diethyl-2,3-dihydro-1H-inden-2-yl)-2,2,2-trifluoroacetamide

HRID 585801Notes

Reaction equation

HRID 585801 reaction equation
[C:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][C:12]=1[CH2:13][CH3:14])[CH2:9][CH:8]([NH:15][C:16](=[O:21])[C:17]([F:20])([F:19])[F:18])[CH2:7]2)(=O)[CH3:2].[H][H]>>[CH2:13]([C:12]1[CH:11]=[C:10]2[C:6](=[CH:5][C:4]=1[CH2:1][CH3:2])[CH2:7][CH:8]([NH:15][C:16](=[O:21])[C:17]([F:19])([F:18])[F:20])[CH2:9]2)[CH3:14]

Participants

3

Reactant 2

HCID 10236497N-(5-acetyl-6-ethyl-2,3-dihydro-1H-inden-2-yl)-2,2,2-trifluoroacetamideHCID 178418361HCID 178418361, compound

Product 1

HCID 10171647N-(5,6-diethyl-2,3-dihydro-1H-inden-2-yl)-2,2,2-trifluoroacetamide

Procedure

Preferably in Step (v), N-(5-acetyl-6-ethyl-2,3-dihydro-1H-inden-2-yl)-2,2,2-trifluoroacetamide is treated with hydrogen gas to form N-(5,6-diethyl-2,3-dihydro-1H-inden-2-yl)-2,2,2-trifluoroacetamide having Formula (XIII)

Sources & evidence

ORD record
ord-f16f8f6c976e4d0199c36b7fc912db88
Source dataset
uspto-grants-2005_08
Patent number
US06933410B2

Reaction notes

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