(s)-Tert-butyl 5-methyl-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide → HCID 69415501, compound

HRID 585826Notes

Reaction equation

HRID 585826 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[NH:7][C:8]2[C:13]([CH:14]=1)=[CH:12][C:11]([CH3:15])=[C:10]([C:16]([F:19])([F:18])[F:17])[CH:9]=2)=[O:5])[CH3:2].[C:20]([O:24][C:25]([N:27]1[CH2:31][C@H:30]([CH3:32])OS1(=O)=O)=[O:26])([CH3:23])([CH3:22])[CH3:21]>>[CH2:1]([O:3][C:4]([C:6]1[N:7]([C@H:30]([CH3:32])[CH2:31][NH:27][C:25]([O:24][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:26])[C:8]2[C:13]([CH:14]=1)=[CH:12][C:11]([CH3:15])=[C:10]([C:16]([F:19])([F:17])[F:18])[CH:9]=2)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 11195739(s)-Tert-butyl 5-methyl-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxideHCID 68889854HCID 68889854, compound

Product 1

HCID 69415501HCID 69415501, compound

Procedure

The title compound, m.p.: 103-105° C., EI-MS: m/e=428.1(M+) and α D 20 = - 40.3 , was prepared in accordance with the general method of example 12b) from 5-methyl-6-trifluoromethyl-1H-indole-2-carboxylic acid ethyl ester and (S)-5-methyl-2,2-dioxo-[1,2,3]oxathiazolidine-3-carboxylic acid tert-butyl ester. e) (R)-4,8-Dimethyl-7-trifluoromethyl-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one

Sources & evidence

ORD record
ord-ca8ffc4dc13548d1a5df728478a8b4d0
Source dataset
uspto-grants-2005_08
Patent number
US06933387B2

Reaction notes

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