p-Aminoacetophenone → HCID 66832003, compound

HRID 58585Notes

Reaction equation

HRID 58585 reaction equation
CC1(C)[O:9][C:8](=[O:10])[C:5]2([CH2:7][CH2:6]2)[C:4](=[O:11])O1.[NH2:13][C:14]1[CH:19]=[CH:18][C:17]([C:20](=[O:22])[CH3:21])=[CH:16][CH:15]=1>C(O)C>[C:20]([C:17]1[CH:18]=[CH:19][C:14]([N:13]2[CH2:6][CH2:7][CH:5]([C:8]([OH:9])=[O:10])[C:4]2=[O:11])=[CH:15][CH:16]=1)(=[O:22])[CH3:21]

Participants

4

Reactant 2

HCID 7468p-AminoacetophenoneHCID 797206,6-Dimethyl-5,7-dioxaspiro(2.5)octane-4,8-dione

Product 1

HCID 66832003HCID 66832003, compoundYield 104.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

This compound was prepared according to general method 1 starting from 6,6-dimethyl-5,7-dioxaspiro[2.5]octane-4,8-dione (0.500 g, 2.94 mmol) and 1-(4-aminophenyl) ethanone (1.19 g, 1.19 mmol) in ethanol (3 mL). 1-(4-acetylphenyl)-2-oxopyrrolidine-3-carboxylic acid 0.307 g (42%) was obtained as a bright yellow solid.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-f5c65cdad574442fb8754d5652db2884
Source dataset
uspto-grants-2016_09
Patent number
US09434722B2

Reaction notes

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