HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Trifluoromethyl)aniline → 2-Oxo-1-(4-(trifluoromethyl)phenyl)pyrrolidine-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Trifluoromethyl)aniline | HCID 9964 | — |
| Reactant | 6,6-Dimethyl-5,7-dioxaspiro(2.5)octane-4,8-dione | HCID 79720 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-Oxo-1-(4-(trifluoromethyl)phenyl)pyrrolidine-3-carboxylic acid | HCID 42656556 | 43% |
Reaction Steps
This compound was prepared according to general method 1 starting from 6,6-dimethyl-5,7-dioxaspiro[2.5]octane-4,8-dione (0.500 g, 2.94 mmol) and 4-trifluoromethyl aniline (1.28 mL, 8.82 mmol) in ethanol (3 mL). 2-oxo-1-(4-(trifluoromethyl)phenyl)pyrrolidine-3-carboxylic acid 0.343 g (43%) was obtained as a bright yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09434722B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-5de3d1dd4afb42c3b69e65b4057b2c00 |
| Source note | uspto-grants-2016_09 |