HuagongsheHuagongshe Chemistry Print Report · For research reference only
6,6-Dimethyl-5,7-dioxaspiro(2.5)octane-4,8-dione → 1-(3-Fluoro-4-(trifluoromethyl)phenyl)-2-oxopyrrolidine-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6,6-Dimethyl-5,7-dioxaspiro(2.5)octane-4,8-dione | HCID 79720 | — |
| Reactant | 4-Amino-2-fluorobenzotrifluoride | HCID 2735914 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-(3-Fluoro-4-(trifluoromethyl)phenyl)-2-oxopyrrolidine-3-carboxylic acid | HCID 66832132 | 35% |
Reaction Steps
This compound was prepared according to general method 1 starting from 6,6-dimethyl-5,7-dioxaspiro[2.5]octane-4,8-dione (0.250 g; 1.45 mmol) and 3-fluoro-4-(trifluoromethyl)aniline (0.806 g; 4.36 mmol) in ethanol (3 mL). 1-(3-fluoro-4-(trifluoromethyl)phenyl)-2-oxopyrrolidine-3-carboxylic acid 0.147 g (35%) was obtained as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09434722B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-ade5901debbf4899bc90f0b706af608f |
| Source note | uspto-grants-2016_09 |