反应详情

温度

80 °C

2-(4-Chlorophenyl)-2-methylpropanoic acid (3.85 g, 19.4 mmol) in toluene (5 mL) was treated with thionyl chloride (5.00 g, 3.1 mL) and heated at 80° C. for 2 hours. The cooled solution was concentrated under reduced pressure to provide a yellow oil containing a crystalline residue. The mixture was dissolved in hexane, filtered and the filtrate concentrated to provide the compound as a pale yellow oil (4.10 g, 98%).

1. concentrationThe cooled solution was concentrated under reduced pressure
2. customto provide a yellow oil
3. additioncontaining a crystalline residue
4. filtrationfiltered
5. concentrationthe filtrate concentrated